RPH Global Vancomycin Calculator

Vancomycin Kinetics Formulas:

\[ ke = 0.00083 \times CrCl + 0.0044 \] \[ Vd = 0.7 \times weight \] \[ Dose = \frac{AUC \times (1 - e^{-ke \times tau})}{ke \times (1 - e^{-ke \times inf})} \]

Creatinine Clearance (CrCl):

mL/min

Patient Weight:

Target AUC:

mg*h/L

Dosing Interval (τ):

hours

Infusion Time:

hours

Elimination Rate (ke): 1/h

Volume of Distribution (Vd): L

Recommended Dose: mg

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1. What is the RPH Global Vancomycin Calculator?

Definition: This calculator determines the appropriate vancomycin dose based on patient-specific pharmacokinetic parameters.

Purpose: It helps clinicians optimize vancomycin dosing to achieve target AUC values for efficacy and safety.

2. How Does the Calculator Work?

The calculator uses three key formulas:

\[ ke = 0.00083 \times CrCl + 0.0044 \] \[ Vd = 0.7 \times weight \] \[ Dose = \frac{AUC \times (1 - e^{-ke \times tau})}{ke \times (1 - e^{-ke \times inf})} \]

Where:

\( ke \) — Elimination rate constant (1/h)
\( CrCl \) — Creatinine clearance (mL/min)
\( Vd \) — Volume of distribution (L)
\( weight \) — Patient weight (kg)
\( AUC \) — Target area under the curve (mg*h/L)
\( tau \) — Dosing interval (hours)
\( inf \) — Infusion time (hours)

Explanation: The calculator first estimates vancomycin clearance using CrCl, then calculates the dose needed to achieve the target AUC.

3. Importance of AUC-Based Dosing

Details: AUC-guided dosing is recommended over trough-only monitoring as it better predicts efficacy and reduces nephrotoxicity risk.

4. Using the Calculator

Tips: Enter patient's CrCl, weight, desired AUC (typically 400-600 for serious infections), dosing interval, and infusion time.

5. Frequently Asked Questions (FAQ)

Q1: What is the typical target AUC range?
A: For serious MRSA infections: 400-600 mg*h/L. Lower ranges may be used for less severe infections.

Q2: How is CrCl estimated?
A: Use Cockcroft-Gault equation: [(140-age) × weight] / (72 × SCr) (×0.85 for females).

Q3: Why is Vd fixed at 0.7 L/kg?
A: This is the population average for vancomycin. Actual Vd may vary in special populations.

Q4: What infusion time should I use?
A: Standard is 1 hour, but 1.5-2 hours may be used for doses >1g or to reduce infusion reactions.

Q5: How should doses be rounded?
A: Round to nearest 100-250mg, considering available vial sizes (typically 500mg, 1g, etc.).