1. What is the Global RPH Carbo Calculator?

Definition: This calculator determines the appropriate carboplatin dose based on the target Area Under the Curve (AUC) and the patient's Glomerular Filtration Rate (GFR).

Purpose: It helps healthcare professionals calculate precise carboplatin chemotherapy doses for optimal treatment efficacy and safety.

2. How Does the Calculator Work?

The calculator uses the formula:

Where:

• \( \text{Dose} \) — Carboplatin dose in milligrams (mg)
• \( \text{AUC} \) — Target Area Under the Curve (mg/mL·min)
• \( \text{GFR} \) — Glomerular Filtration Rate (mL/min)

Explanation: The formula accounts for both drug exposure (AUC) and kidney function (GFR) to determine the appropriate dose.

3. Importance of Accurate Carboplatin Dosing

Details: Proper dosing ensures therapeutic effectiveness while minimizing toxicity, especially important for this nephrotoxic drug.

4. Using the Calculator

Tips: Enter the target AUC (typically 4-7 mg/mL·min for most regimens) and the patient's GFR (measured or estimated). All values must be > 0.

5. Frequently Asked Questions (FAQ)

Q1: What is AUC in carboplatin dosing?
A: AUC (Area Under the Curve) represents drug exposure over time and is the preferred method for carboplatin dosing.

Q2: How is GFR determined?
A: GFR can be measured directly or estimated using formulas like Cockcroft-Gault or MDRD.

Q3: Why is there a +25 in the formula?
A: The +25 accounts for non-renal clearance of carboplatin and helps prevent underdosing.

Q4: What are typical AUC values?
A: Common ranges are 4-6 for adjuvant therapy, 5-7 for advanced disease, but always follow protocol-specific targets.

Q5: Are there maximum dose limits?
A: Some protocols specify maximum doses (e.g., 800-1000mg) regardless of calculation - always check guidelines.